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    Glycine Receptor
    Experiments, Studies and Background Information
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    Glycine Receptor Experiments

    • The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study [View Experiment]
    • Repetitive Light Stimulation Inducing Glycine Receptor Plasticity in the Retinal Neurons [View Experiment]
    • Kinetic Analysis of Glycine Receptor Currents in Ventral Cochlear Nucleus [View Experiment]
    • Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells [View Experiment]
    • A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate [View Experiment]
    • M2 Pore Mutations Convert the Glycine Receptor Channel from Being Anion- to Cation-Selective [View Experiment]
    • Thesis: Preclinical Investigations of Glyt-1 Inhibition as a New Concept for Treatment of Alcohol Dependence [View Experiment]
    • Gamma-Aminobutyric Acid-containing Terminals Can Be Apposed to Glycine Receptors at Central Synapses [View Experiment]
    Glycine Receptor Background Information

    Definition

    The glycine receptor, or GlyR, is the receptor for the amino acid neurotransmitter glycine.

    Basics

    The glycine receptor is one of the most widely distributed inhibitory receptors in the central nervous system and has important roles in a variety of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brain stem.

    Activation and inactivation: The receptor can be activated by a range of simple amino acids including glycine, β-alanine and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine. Caffeine has recently been found also to be a competitive antagonist.

    Arrangement of subunits: Strychnine-sensitive glycine receptors are members of a family of Ligand-gated ion channels. Receptors of this family are arranged as five subunits surrounding a central pore, with each subunit composed of four α helical transmembrane segments.

    There are presently four known isoforms of the α-subunit (α1-4) of GlyR that are essential to bind ligands (GLRA1, GLRA2, GLRA3, GLRA4) and a single β-subunit (GLRB).

    The adult form of the GlyR is the heteromeric α1β receptor, which is believed to have a stoichiometry (proportion) of three α1 subunits and two β subunits or four α1 subunits and one β subunit. The α-subunits are also able to form functional homo-pentameric receptors in heterologous expression systems in African clawed frog's oocytes or mammalian cell lines, and the α1 homomeric receptor is essential for studies of channel pharmacokinetics and pharmacodynamics.

    Glycine receptors in diseases: Disruption of GlyR surface expression or reduced ability of expressed GlyRs to conduct chloride ions results in the rare neurological disorder, hyperekplexia. The disorder is characterized by an exaggerated response to unexpected stimuli which is followed by a temporary but complete muscular rigidity often resulting in an unprotected fall. Chronic injuries as a result of the falls are symptomatic of the disorder. A mutation in GLRA1 is responsible for some cases of stiff person syndrome.

    Quantum dots have been used to track the diffusion of glycine receptors into the synapse of neurons.

    Topics of Interest

    Glycine (abbreviated as Gly or G) is an organic compound with the formula NH2CH2COOH. With only a hydrogen atom as its side chain, glycine is the smallest of the 20 amino acids commonly found in proteins.

    Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene.

    Source: Wikipedia (All text is available under the terms of the GNU Free Documentation License and Creative Commons Attribution-ShareAlike License.)

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